The collision, which took the lives of two people, occurred in the 1400 block of the North Freeway at around 12:35 a.m.
Authorities said the suspect was driving a black Dodge Charger northbound in the southbound freeway when she collided with a black Kia Rio and a gray Kia Soul, both heading southbound.
Two occupants in the Kia Rio, a 31-year-old man and a 30-year-old woman, died from their injuries at the scene.
The driver of the Kia suffered non-life-threatening injuries and was transported to a local hospital.
Authorities said the wrong-way driver also sustained non-life-threatening injuries and was hospitalized. She is now charged with two counts of intoxication manslaughter after having displayed signs of impairment at the scene.
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