Houston Police Department said the fatal crash happened near the 200 block of East Little York Road shortly after noon.
A preliminary investigation indicates a Freightliner semi-truck was from Northline Drive onto East Little York Road when it struck the cyclist, who was riding southbound.
The victim was pronounced on the scene, confirmed authorities.
The driver of the Freightliner stayed after the crash and was questioned by officers but was released.
An investigation remains ongoing. At this time, HPD’s Vehicular Crimes Division has not released findings on which party had the right-of-way.
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